1nko
From Proteopedia
(New page: 200px<br /> <applet load="1nko" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nko, resolution 1.45Å" /> '''Energetic and struc...) |
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| - | [[Image:1nko.gif|left|200px]]<br /> | + | [[Image:1nko.gif|left|200px]]<br /><applet load="1nko" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1nko" size=" | + | |
caption="1nko, resolution 1.45Å" /> | caption="1nko, resolution 1.45Å" /> | ||
'''Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7'''<br /> | '''Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The high-resolution crystal structure of the functional N-terminal domain | + | The high-resolution crystal structure of the functional N-terminal domain from the extracellular region of the human natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7 has been determined at 1.45 A resolution; it was obtained from a crystal belonging to a primitive monoclinic space group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha = gamma = 90, beta = 113 degrees. The structure reported here belongs to a different space group than the previously described Siglec-7 structure and was obtained using a bacterial expression system. The structure unveils the fine structural requirements adopted by a natural killer cell inhibitory receptor of the Siglec family in target-cell recognition and binding. |
==About this Structure== | ==About this Structure== | ||
| - | 1NKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1NKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Aalten, D | + | [[Category: Aalten, D M.F van.]] |
[[Category: Attril, H.]] | [[Category: Attril, H.]] | ||
[[Category: Biassoni, R.]] | [[Category: Biassoni, R.]] | ||
[[Category: Dimasi, N.]] | [[Category: Dimasi, N.]] | ||
| - | [[Category: Mariuzza, R | + | [[Category: Mariuzza, R A.]] |
[[Category: Moretta, L.]] | [[Category: Moretta, L.]] | ||
[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
[[Category: siglec7]] | [[Category: siglec7]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:07:06 2008'' |
Revision as of 12:07, 21 February 2008
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Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7
Overview
The high-resolution crystal structure of the functional N-terminal domain from the extracellular region of the human natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7 has been determined at 1.45 A resolution; it was obtained from a crystal belonging to a primitive monoclinic space group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha = gamma = 90, beta = 113 degrees. The structure reported here belongs to a different space group than the previously described Siglec-7 structure and was obtained using a bacterial expression system. The structure unveils the fine structural requirements adopted by a natural killer cell inhibitory receptor of the Siglec family in target-cell recognition and binding.
About this Structure
1NKO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1., Dimasi N, Moretta A, Moretta L, Biassoni R, Mariuzza RA, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):401-3. Epub 2004, Jan 23. PMID:14747738
Page seeded by OCA on Thu Feb 21 14:07:06 2008
