2r4f
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[2r4f]] is a 4 chain structure | + | [[2r4f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4F OCA]. |
==See Also== | ==See Also== | ||
Revision as of 19:17, 20 October 2012
Contents |
Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
Template:ABSTRACT PUBMED 18072721
About this Structure
2r4f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r
Categories: Homo sapiens | Finzel, B C. | Harris, M S. | Pavlovsky, A. | Pfefferkorn, J A. | Biocynthesis | Cholesterol | Cholesterol biosynthesis | Endoplasmic reticulum | Glycoprotein | Hmg-coa | Lipid synthesis | Membrane | Nadph | Oxidoreductase | Peroxisome | Statin | Steroid biosynthesis | Sterol biosynthesis | Transmembrane
