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1nw2

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(New page: 200px<br /><applet load="1nw2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nw2, resolution 1.90&Aring;" /> '''The crystal structur...)

Revision as of 12:10, 21 February 2008

Image:1nw2.jpg

1nw2, resolution 1.90Å

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The crystal structure of the mutant R82E of Thioredoxin from Alicyclobacillus acidocaldarius

Overview

We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.

About this Structure

1NW2 is a Single protein structure of sequence from Alicyclobacillus acidocaldarius with , and as ligands. Active as Thioredoxin-disulfide reductase, with EC number 1.8.1.9 Full crystallographic information is available from OCA.

Reference

An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius., Bartolucci S, De Simone G, Galdiero S, Improta R, Menchise V, Pedone C, Pedone E, Saviano M, J Bacteriol. 2003 Jul;185(14):4285-9. PMID:12837806

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