3dxc

(Difference between revisions)

Revision as of 21:27, 20 October 2012

3dxc, resolution 2.10Å ()

Gene:

APBB1, FE65, RIR (Homo sapiens), APP, A4, AD1 (Homo sapiens)

Related:

3dxd, 3dxe

Structural annotation:
Resources:	InterPro : Ipr001202, Ipr006020, Ipr011993, Ipr002223, Ipr008154, Ipr008155, Ipr011178, Ipr013803, Ipr015849 Pfam : PF00640 UniProt : O00213, P05067

Functional annotation:
Cellular component:	nucleus lamellipodium synapse growth cone extracellular region integral to membrane integral to plasma membrane platelet alpha granule lumen coated pit cell surface membrane
Biological process:	signal transduction regulation of transcription negative regulation of cell growth axonogenesis cell cycle arrest negative regulation of thymidylate synthase biosynthetic process negative regulation of S phase of mitotic cell cycle cell adhesion apoptosis endocytosis cellular copper ion homeostasis Notch signaling pathway neuromuscular process
Molecular function:	beta-amyloid binding transcription factor binding protein binding heparin binding endopeptidase inhibitor activity metal ion binding binding identical protein binding zinc ion binding copper ion binding acetylcholine receptor binding iron ion binding serine-type endopeptidase inhibitor activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

3dxc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K. Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. EMBO Rep. 2008 Nov;9(11):1134-40. Epub 2008 Oct 3. PMID:18833287 doi:http://dx.doi.org/10.1038/embor.2008.188
Radzimanowski J, Beyreuther K, Sinning I, Wild K. Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):409-12. Epub 2008 Apr 24. PMID:18453713 doi:http://dx.doi.org/10.1107/S1744309108009524

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 ==About this Structure==
-[[3dxc]] is a 4 chain structure of [[Amyloid precursor protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXC OCA].
+[[3dxc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXC OCA].
 ==See Also==