1o9m
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The ribosome is an important target for aminoglycoside antibiotics; | + | The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes. |
==About this Structure== | ==About this Structure== | ||
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The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12643685 12643685] | The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12643685 12643685] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Murray, J | + | [[Category: Murray, J B.]] |
[[Category: Russell, R.]] | [[Category: Russell, R.]] | ||
[[Category: 42B]] | [[Category: 42B]] | ||
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[[Category: rna-antibiotic interactions]] | [[Category: rna-antibiotic interactions]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:15:02 2008'' |
Revision as of 12:15, 21 February 2008
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THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.
Overview
The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.
About this Structure
1O9M is a Single protein structure of sequence from [1] with , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685
Page seeded by OCA on Thu Feb 21 14:15:02 2008
Categories: Single protein | Murray, J B. | Russell, R. | 42B | BDG | P24 | PA2 | A-site | Rna-antibiotic interactions
