1ocn
From Proteopedia
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==Overview== | ==Overview== | ||
| - | A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 | + | A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Humicola insolens]] | [[Category: Humicola insolens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Davies, G | + | [[Category: Davies, G J.]] |
| - | [[Category: Gilbert, H | + | [[Category: Gilbert, H J.]] |
[[Category: Macdonald, J.]] | [[Category: Macdonald, J.]] | ||
[[Category: Pell, G.]] | [[Category: Pell, G.]] | ||
| - | [[Category: Stick, R | + | [[Category: Stick, R V.]] |
[[Category: Varrot, A.]] | [[Category: Varrot, A.]] | ||
[[Category: BGC]] | [[Category: BGC]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:16:05 2008'' |
Revision as of 12:16, 21 February 2008
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MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION
Overview
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
About this Structure
1OCN is a Single protein structure of sequence from Humicola insolens with , , and as ligands. Active as Cellulose 1,4-beta-cellobiosidase, with EC number 3.2.1.91 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases., Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312
Page seeded by OCA on Thu Feb 21 14:16:05 2008
