1od8
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | The atomic-resolution structure of a xylobiose-derived isofagomine lactam | + | The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base. |
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces lividans]] | [[Category: Streptomyces lividans]] | ||
| - | [[Category: Davies, G | + | [[Category: Davies, G J.]] |
| - | [[Category: Gloster, T | + | [[Category: Gloster, T M.]] |
[[Category: Roberts, S.]] | [[Category: Roberts, S.]] | ||
[[Category: IMD]] | [[Category: IMD]] | ||
| Line 29: | Line 29: | ||
[[Category: xylanase]] | [[Category: xylanase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:16:20 2008'' |
Revision as of 12:16, 21 February 2008
|
XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM
Overview
The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.
About this Structure
1OD8 is a Single protein structure of sequence from Streptomyces lividans with , , and as ligands. Active as Endo-1,4-beta-xylanase, with EC number 3.2.1.8 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer., Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311
Page seeded by OCA on Thu Feb 21 14:16:20 2008
