1oht
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The family of peptidoglycan recognition proteins (PGRPs) are associated | + | The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Byun, M.]] | [[Category: Byun, M.]] | ||
| - | [[Category: Kim, M | + | [[Category: Kim, M S.]] |
| - | [[Category: Oh, B | + | [[Category: Oh, B H.]] |
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: TLA]] | [[Category: TLA]] | ||
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[[Category: peptidoglycan-recognition protein-lb isoform 2]] | [[Category: peptidoglycan-recognition protein-lb isoform 2]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:17:54 2008'' |
Revision as of 12:17, 21 February 2008
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PEPTIDOGLYCAN RECOGNITION PROTEIN-LB
Overview
The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components.
About this Structure
1OHT is a Single protein structure of sequence from Drosophila melanogaster with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:12845326
Page seeded by OCA on Thu Feb 21 14:17:54 2008
