1okx
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Natural bioactive compounds are of general interest to pharmaceutical | + | Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Matern, U.]] | [[Category: Matern, U.]] | ||
[[Category: Schleberger, C.]] | [[Category: Schleberger, C.]] | ||
| - | [[Category: Schulz, G | + | [[Category: Schulz, G E.]] |
[[Category: Weckesser, J.]] | [[Category: Weckesser, J.]] | ||
[[Category: elastase]] | [[Category: elastase]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:18:52 2008'' |
Revision as of 12:18, 21 February 2008
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BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A
Overview
Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors.
About this Structure
1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Active as Pancreatic elastase, with EC number 3.4.21.36 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266
Page seeded by OCA on Thu Feb 21 14:18:52 2008
