1cjb

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Revision as of 20:07, 21 October 2012

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Template:STRUCTURE 1cjb

MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE

Template:ABSTRACT PUBMED 10433693

About this Structure

1cjb is a 4 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

• Shi W, Li CM, Tyler PC, Furneaux RH, Cahill SM, Girvin ME, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry. 1999 Aug 3;38(31):9872-80. PMID:10433693 doi:10.1021/bi990664p
• Joshi AA, Viswanathan CL. Docking studies and development of novel 5-heteroarylamino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as potential antimalarials. Bioorg Med Chem Lett. 2006 May 15;16(10):2613-7. Epub 2006 Mar 3. PMID:16516468 doi:10.1016/j.bmcl.2006.02.038