1p2a
From Proteopedia
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==Overview== | ==Overview== | ||
| - | A novel class of 3,5,6-trisubstituted naphthostyril analogues was designed | + | A novel class of 3,5,6-trisubstituted naphthostyril analogues was designed and synthesized to study the structure-activity relationship for inhibition of cyclin-dependent kinase 2 (CDK2). These compounds, particularly molecules with side-chain modifications providing additional hydrogen bonding capability, were demonstrated to be potent CDK2 inhibitors with cellular activities consistent with CDK2 inhibition. These molecules inhibited tumor cell proliferation and G1-S and G2-M cell-cycle progression in vitro. The X-ray crystal structure of a 2-aminoethyleneamine derivative bound to CDK2, refined to 2.5A resolution, is presented. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Kammlott, U.]] | [[Category: Kammlott, U.]] | ||
[[Category: Konzelmann, F.]] | [[Category: Konzelmann, F.]] | ||
| - | [[Category: Liu, J | + | [[Category: Liu, J J.]] |
| - | [[Category: Luk, K | + | [[Category: Luk, K C.]] |
| - | [[Category: Lukacs, C | + | [[Category: Lukacs, C M.]] |
[[Category: Schutt, A.]] | [[Category: Schutt, A.]] | ||
| - | [[Category: Simcox, M | + | [[Category: Simcox, M E.]] |
[[Category: Yang, H.]] | [[Category: Yang, H.]] | ||
[[Category: Yin, X.]] | [[Category: Yin, X.]] | ||
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[[Category: naphthostyril oxindole]] | [[Category: naphthostyril oxindole]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:24:17 2008'' |
Revision as of 12:24, 21 February 2008
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The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor
Overview
A novel class of 3,5,6-trisubstituted naphthostyril analogues was designed and synthesized to study the structure-activity relationship for inhibition of cyclin-dependent kinase 2 (CDK2). These compounds, particularly molecules with side-chain modifications providing additional hydrogen bonding capability, were demonstrated to be potent CDK2 inhibitors with cellular activities consistent with CDK2 inhibition. These molecules inhibited tumor cell proliferation and G1-S and G2-M cell-cycle progression in vitro. The X-ray crystal structure of a 2-aminoethyleneamine derivative bound to CDK2, refined to 2.5A resolution, is presented.
About this Structure
1P2A is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors., Liu JJ, Dermatakis A, Lukacs C, Konzelmann F, Chen Y, Kammlott U, Depinto W, Yang H, Yin X, Chen Y, Schutt A, Simcox ME, Luk KC, Bioorg Med Chem Lett. 2003 Aug 4;13(15):2465-8. PMID:12852944
Page seeded by OCA on Thu Feb 21 14:24:17 2008
