1p53
From Proteopedia
(New page: 200px<br /> <applet load="1p53" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p53, resolution 3.06Å" /> '''The Crystal Structu...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1p53.gif|left|200px]]<br /> | + | [[Image:1p53.gif|left|200px]]<br /><applet load="1p53" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1p53" size=" | + | |
caption="1p53, resolution 3.06Å" /> | caption="1p53, resolution 3.06Å" /> | ||
'''The Crystal Structure of ICAM-1 D3-D5 fragment'''<br /> | '''The Crystal Structure of ICAM-1 D3-D5 fragment'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the 3.0 A crystal structure of the three C-terminal | + | We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1P53 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and NDG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1P53 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=NDG:'>NDG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P53 OCA]. |
==Reference== | ==Reference== | ||
| Line 18: | Line 17: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Jochimiak, A.]] | [[Category: Jochimiak, A.]] | ||
| - | [[Category: Jun, C | + | [[Category: Jun, C D.]] |
| - | [[Category: Liu, J | + | [[Category: Liu, J H.]] |
| - | [[Category: Springer, T | + | [[Category: Springer, T A.]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J H.]] |
[[Category: Yang, Y.]] | [[Category: Yang, Y.]] | ||
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
| Line 30: | Line 29: | ||
[[Category: igsf domain]] | [[Category: igsf domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:12 2008'' |
Revision as of 12:25, 21 February 2008
|
The Crystal Structure of ICAM-1 D3-D5 fragment
Contents |
Overview
We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling.
Disease
Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]
About this Structure
1P53 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:15099525
Page seeded by OCA on Thu Feb 21 14:25:12 2008
Categories: Homo sapiens | Single protein | Jochimiak, A. | Jun, C D. | Liu, J H. | Springer, T A. | Wang, J H. | Yang, Y. | Zhang, R. | NAG | NDG | Beta-sheet | Dimer | Igsf domain
