1azs
From Proteopedia
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Revision as of 12:48, 30 October 2007
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
Overview
The crystal structure of a soluble, catalytically active form of adenylyl, cyclase in a complex with its stimulatory heterotrimeric G protein alpha, subunit (Gsalpha) and forskolin was determined to a resolution of 2.3, angstroms. When P-site inhibitors were soaked into native crystals of the, complex, the active site of adenylyl cyclase was located and structural, elements important for substrate recognition and catalysis were, identified. On the basis of these and other structures, a molecular, mechanism is proposed for the activation of adenylyl cyclase by Gsalpha.
About this Structure
1AZS is a [Protein complex] structure of sequences from [Bos taurus], [Canis lupus familiaris] and [Rattus norvegicus] with MG, GSP and FKP as [ligands]. Active as [Adenylate cyclase], with EC number [4.6.1.1]. Structure known Active Site: MGB. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS., Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR, Science. 1997 Dec 12;278(5345):1907-16. PMID:9417641
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