Group:MUZIC:Telethonin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(→Telethonin)
(→Telethonin)
Line 27: Line 27:
-
Telethonin accumulation is restricted to striated muscle, being found mostly in skeletal and cardiac muscle. It is one of the major components of the sarcomere and localizes to the Z-disc. It was also reported a nuclear localization.<ref>PMID:12379311 </ref>, <ref name="a"> PMID:16678796 </ref>
+
Telethonin accumulation is restricted to striated muscle, being found mostly in skeletal and cardiac muscle. It is one of the major components of the sarcomere and localizes to the Z-disc. It was also reported to localize to the nucleus.<ref>PMID:12379311 </ref>, <ref name="a"> PMID:16678796 </ref>
-
Studies on telethonin structure by Zou et al. <ref name="b"> PMID:16407954 </ref> report that it is made up of <scene name='User:Marcia_Ivonne_Pena_Paz/workbench/Telethonin/Telethonin_nter_cter/1'>five stranded antiparallel β-sheets extended by two wing-shaped β-hairpin motifs (A-B, C-D). These two motifs are related by an approximate two-fold symmetry, which generates an almost perfect palindromic arrangement.</scene> (N-terminal in blue and C-ter in orange). This structure is only found in the presence of titin, it might adopt a different fold in its absence.
+
Studies on telethonin structure by Zou et al. <ref name="b"> PMID:16407954 </ref> report that it is made up of <scene name='User:Marcia_Ivonne_Pena_Paz/workbench/Telethonin/Telethonin_nter_cter/1'>five stranded antiparallel β-sheets extended by two wing-shaped β-hairpin motifs (A-B, C-D). These two motifs are related by an approximate two-fold symmetry, which generates an almost perfect palindromic arrangement.</scene> (N-terminal in blue and C-ter in orange). This structure is only found in the presence of titin, Telethonin might adopt a different fold in its absence.
-
The structure of telethonin was determined using X-ray crystallography. <ref>PMID:12446666</ref>,<ref name="b" /> The shape and architecture of the complex of titin/telethonin was studied by small-angle- X-ray scattering (SAXS) and then compared to the crystallographic models. They also used in-vitro experiments to follow the formation of the complex in non-myogenic Cos1 cells, in order to understand if the assemblage is possible <ref>PMID:16713295</ref>
+
The structure of telethonin was determined using X-ray crystallography. <ref>PMID:12446666</ref>,<ref name="b" /> The shape and architecture of the complex of titin/telethonin was studied by small-angle- X-ray scattering (SAXS) and then compared to the crystallographic models. <ref>PMID:16713295</ref>
This symmetry of telethonin permits its interaction with titin. Both are assembled in an antiparallel <scene name='User:Marcia_Ivonne_Pena_Paz/workbench/Telethonin/Telethonin-titin/1'>sandwich 2:1</scene> (titin:telethonin). Titin N-terminal domains Z1 and Z2 (two Ig like repeats) interact with the C-terminal region of telethonin (residues 1-53). Telethonin mediates in the antiparallel assembly of the two Z1Z2domains.
This symmetry of telethonin permits its interaction with titin. Both are assembled in an antiparallel <scene name='User:Marcia_Ivonne_Pena_Paz/workbench/Telethonin/Telethonin-titin/1'>sandwich 2:1</scene> (titin:telethonin). Titin N-terminal domains Z1 and Z2 (two Ig like repeats) interact with the C-terminal region of telethonin (residues 1-53). Telethonin mediates in the antiparallel assembly of the two Z1Z2domains.

Revision as of 12:06, 25 October 2012

Telethonin

Telethonin crystal structure by Zou et al. (2006) interacting with Z1 and Z2 titin domains(PDB entry 1ya5)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Marcia Ivonne Peña Paz, Nikos Pinotsis, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Group:MUZIC:Telethonin"
Personal tools