1pcf
From Proteopedia
(New page: 200px<br /> <applet load="1pcf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pcf, resolution 1.74Å" /> '''HUMAN TRANSCRIPTION...) |
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| - | [[Image:1pcf.gif|left|200px]]<br /> | + | [[Image:1pcf.gif|left|200px]]<br /><applet load="1pcf" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1pcf" size=" | + | |
caption="1pcf, resolution 1.74Å" /> | caption="1pcf, resolution 1.74Å" /> | ||
'''HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN'''<br /> | '''HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of human replication and transcription cofactor | + | The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication. |
==About this Structure== | ==About this Structure== | ||
| - | 1PCF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1PCF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transcriptional cofactor]] | [[Category: transcriptional cofactor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:27:21 2008'' |
Revision as of 12:27, 21 February 2008
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HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN
Overview
The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.
About this Structure
1PCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site., Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P, Nat Struct Biol. 1997 Nov;4(11):900-3. PMID:9360603
Page seeded by OCA on Thu Feb 21 14:27:21 2008
