1pkt
From Proteopedia
(New page: 200px<br /> <applet load="1pkt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pkt" /> '''STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYS...) |
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'''STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY'''<br /> | '''STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Src homology 3 (SH3) domains, which are found in many proteins involved in | + | Src homology 3 (SH3) domains, which are found in many proteins involved in intracellular signal transduction, mediate specific protein-protein interactions. The three-dimensional structure of the SH3 domain in the p85 subunit of the phosphatidylinositol 3-kinase (PI3K) has been determined by multidimensional NMR methods. The molecule consists of four short helices, two beta turns, and two antiparallel beta sheets. The beta sheets are highly similar to corresponding regions in the SH3 domain of the tyrosine kinase Src, even though the sequence identity of the two domains is low. There is a unique 15 amino acid insert in PI3K that contains three short helices. There are substantial differences in the identity of the amino acids that make up the receptor site of SH3 domains. The results suggest that while the overall structures of the binding sites in the PI3K and Src SH3 domains are similar, their ligand binding properties may differ. |
==About this Structure== | ==About this Structure== | ||
| - | 1PKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] Full crystallographic information is available from [http:// | + | 1PKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Phosphatidylinositol 3-kinase]] | [[Category: Phosphatidylinositol 3-kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Dalgarno, D | + | [[Category: Dalgarno, D C.]] |
[[Category: Koyama, S.]] | [[Category: Koyama, S.]] | ||
| - | [[Category: Schreiber, S | + | [[Category: Schreiber, S L.]] |
| - | [[Category: Shin, T | + | [[Category: Shin, T B.]] |
[[Category: Yu, H.]] | [[Category: Yu, H.]] | ||
| - | [[Category: Zydowsky, L | + | [[Category: Zydowsky, L D.]] |
[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:29:51 2008'' |
Revision as of 12:29, 21 February 2008
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STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY
Overview
Src homology 3 (SH3) domains, which are found in many proteins involved in intracellular signal transduction, mediate specific protein-protein interactions. The three-dimensional structure of the SH3 domain in the p85 subunit of the phosphatidylinositol 3-kinase (PI3K) has been determined by multidimensional NMR methods. The molecule consists of four short helices, two beta turns, and two antiparallel beta sheets. The beta sheets are highly similar to corresponding regions in the SH3 domain of the tyrosine kinase Src, even though the sequence identity of the two domains is low. There is a unique 15 amino acid insert in PI3K that contains three short helices. There are substantial differences in the identity of the amino acids that make up the receptor site of SH3 domains. The results suggest that while the overall structures of the binding sites in the PI3K and Src SH3 domains are similar, their ligand binding properties may differ.
About this Structure
1PKT is a Single protein structure of sequence from Homo sapiens. Active as Phosphatidylinositol 3-kinase, with EC number 2.7.1.137 Full crystallographic information is available from OCA.
Reference
Structure of the PI3K SH3 domain and analysis of the SH3 family., Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL, Cell. 1993 Mar 26;72(6):945-52. PMID:7681364
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