1pmi
From Proteopedia
(New page: 200px<br /><applet load="1pmi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pmi, resolution 1.7Å" /> '''HUMAN RANTES'''<br />...) |
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| - | [[Image:1pmi.gif|left|200px]]<br /><applet load="1pmi" size=" | + | [[Image:1pmi.gif|left|200px]]<br /><applet load="1pmi" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1pmi, resolution 1.7Å" /> | caption="1pmi, resolution 1.7Å" /> | ||
'''HUMAN RANTES'''<br /> | '''HUMAN RANTES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Phosphomannose isomerase (PMI) catalyses the reversible isomerization of | + | Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other. |
==About this Structure== | ==About this Structure== | ||
| - | 1PMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] Full crystallographic information is available from [http:// | + | 1PMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mannose-6-phosphate isomerase]] | [[Category: Mannose-6-phosphate isomerase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bernard, A | + | [[Category: Bernard, A R.]] |
[[Category: Cleasby, A.]] | [[Category: Cleasby, A.]] | ||
| - | [[Category: Davies, G | + | [[Category: Davies, G J.]] |
| - | [[Category: Hubbard, R | + | [[Category: Hubbard, R E.]] |
| - | [[Category: Payton, M | + | [[Category: Payton, M A.]] |
| - | [[Category: Proudfoot, A | + | [[Category: Proudfoot, A E.I.]] |
[[Category: Skarzynski, T.]] | [[Category: Skarzynski, T.]] | ||
| - | [[Category: Wells, T | + | [[Category: Wells, T N.C.]] |
[[Category: Wonacott, A.]] | [[Category: Wonacott, A.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: aldose-ketose isomerase]] | [[Category: aldose-ketose isomerase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:17 2008'' |
Revision as of 12:30, 21 February 2008
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HUMAN RANTES
Overview
Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.
About this Structure
1PMI is a Single protein structure of sequence from Candida albicans with as ligand. Active as Mannose-6-phosphate isomerase, with EC number 5.3.1.8 Full crystallographic information is available from OCA.
Reference
The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:8612079
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