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1bhs
From Proteopedia
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Revision as of 12:50, 30 October 2007
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HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE
Overview
BACKGROUND: The principal human estrogen, 17 beta-estradiol, is a potent, stimulator of certain endocrine-dependent forms of breast cancer. Because, human estrogenic 17 beta-hydroxysteroid dehydrogenase (type I 17 beta-HSD), catalyzes the last step in the biosynthesis of 17 beta-estradiol from the, less potent estrogen, estrone, it is an attractive target for the design, of inhibitors of estrogen production and tumor growth. This human enzyme, shares less than 15% sequence identity with a bacterial 3 alpha,20, beta-HSD, for which the three-dimensional structure is known. The amino, acid sequence of 17 beta-HSD also differs from that of bacterial 3, alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52, additional residues at the C terminus. RESULTS: The 2.20 A resolution, ... [(full description)]
About this Structure
1BHS is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Estradiol 17-beta-dehydrogenase], with EC number [1.1.1.62]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:7663947
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