Glucosamine 6-phosphate synthase (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP).
3D structures of glucosamine 6-phosphate synthase
2vf4 - EcG6PS – Escherichia coli
3tbf – G6PS C terminal – Francisella tularensis
1moq, 2vf5 – EcG6PS + G6P
1mor, 1jxa – EcG6PS + glucose 6-phosphate
1xff - EcG6PS glutaminase domain + glutamate
1xfg - EcG6PS glutaminase domain + glutamic hydroxamate
1mos – EcG6PS + ADGP
2bpl – EcG6PS + F6P
2j6h - EcG6PS + oxo-norleucine + glucose 6-phosphate
