Ire1
From Proteopedia
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| - | <StructureSection load='3lj1' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain complex with inhibitor (PDB entry [[3lj1]])' scene=''> | + | <StructureSection load='3lj1' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with inhibitor (PDB entry [[3lj1]])' scene=''> |
'''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation. | '''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation. | ||
Revision as of 10:35, 5 November 2012
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