Journal:JBSD:2
From Proteopedia
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | <scene name='Journal:JBSD:2/Cv/2'>Neurotensin (NT) is a tridecapeptide</scene>, hormone in the periphery and neurotransmitter in the brain. We used high-resolution nuclear magnetic resonance (NMR) to resolve the three-dimensional structure of NT in a small unilamellar vesicle (SUV) environment. We demonstrate that if the <scene name='Journal:JBSD:2/Cv/3'>dynamic</scene> of the association–dissociation processes of peptide to SUV binding is rapid enough, structural determination can be obtained by solution NMR experiments. Thus, according to the global dynamic of the system, SUVs seem to be an effective model to mimic biological membranes, especially since the lipid composition can be modified or sterols may be added to closely mimic the biological membranes studied. | + | <scene name='Journal:JBSD:2/Cv/2'>Neurotensin (NT) is a tridecapeptide</scene>, hormone in the periphery and neurotransmitter in the brain. We used high-resolution <scene name='Journal:JBSD:2/Cv/4'>nuclear magnetic resonance (NMR) to resolve the three-dimensional structure of NT</scene> in a small unilamellar vesicle (SUV) environment. We demonstrate that if the <scene name='Journal:JBSD:2/Cv/3'>dynamic</scene> of the association–dissociation processes of peptide to SUV binding is rapid enough, structural determination can be obtained by solution NMR experiments. Thus, according to the global dynamic of the system, SUVs seem to be an effective model to mimic biological membranes, especially since the lipid composition can be modified or sterols may be added to closely mimic the biological membranes studied. |
</StructureSection> | </StructureSection> | ||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
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- ↑ Da Costa G, Bondon A, Delalande O, Mouret L, Monti JP. Elucidation by NMR solution of neurotensin in small unilamellar vesicle environment: molecular surveys for neurotensin receptor recognition. J Biomol Struct Dyn. 2012 Aug 28. PMID:22928939 doi:10.1080/07391102.2012.712459
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