Myosin light chain kinase
From Proteopedia
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| - | {{STRUCTURE_2x4f| PDB=2x4f | SIZE=400| SCENE= |right|CAPTION= | + | {{STRUCTURE_2x4f| PDB=2x4f | SIZE=400| SCENE= |right|CAPTION=Two monomers of human myosin light chain kinase residues 40-388 complex with pyrimidine derivative, pentaethylene glycol, ethanediol and sulfate ion, [[2x4f]] }} |
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Revision as of 11:22, 6 November 2012
Myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin at serine residue 19. This phosphorylation enables the myosin crossbridge to bind to the actin filament and allow muscle contraction to begin. Dephosphorylation of the myosin light chain stops muscle contraction.
3D structures of MLCK
2cqv – hMLCK 8th Ig-like domain – human – NMR
2yr3 - hMLCK 4th Ig-like domain – NMR
2x4f – hMLCK residues 40-388
