Pho4 bHLH Protein

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<Structure load='Insert PDB code or filename here' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />[[Image:3odu.png|left|200px]]
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[[Image:1a0a.png|left|200px]]
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{{STRUCTURE_3odu| PDB=3odu | SCENE= }}
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{{STRUCTURE_1a0a| PDB=1a0a | SCENE= }}
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===The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t===
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===PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX===
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{{ABSTRACT_PUBMED_20929726}}
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{{ABSTRACT_PUBMED_9303313}}
==About this Structure==
==About this Structure==
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[[3odu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODU OCA].
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[[1a0a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0A OCA].
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==See Also==
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*[[CXC chemokine receptor type 4|CXC chemokine receptor type 4]]
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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==Reference==
==Reference==
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<ref group="xtra">PMID:020929726</ref><references group="xtra"/>
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<ref group="xtra">PMID:009303313</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Lysozyme]]
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[[Category: Hakoshima, T.]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
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[[Category: Ihara, K.]]
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[[Category: Cherezov, V.]]
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[[Category: Kyogoku, Y.]]
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[[Category: Chien, E Y.T.]]
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[[Category: Ogawa, N.]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: Oshima, Y.]]
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[[Category: Han, G W.]]
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[[Category: Shimizu, M.]]
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[[Category: Katritch, V.]]
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[[Category: Shimizu, T.]]
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[[Category: Liu, W.]]
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[[Category: Toumoto, A.]]
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[[Category: Mol, C D.]]
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[[Category: Basic helix loop helix]]
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[[Category: Stevens, R C.]]
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[[Category: Transcription factor]]
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[[Category: Wu, B.]]
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[[Category: Transcription-dna complex]]
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[[Category: 7tm]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Atcg3d]]
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[[Category: Cancer]]
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[[Category: Chemokine]]
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[[Category: Chimera]]
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[[Category: Cxcl12]]
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[[Category: G protein-coupled receptor]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Hiv-1 co-receptor]]
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[[Category: Hydrolase]]
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[[Category: Isothiourea]]
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[[Category: Membrane protein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Psi-biology]]
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[[Category: Sdf1]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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[[Category: Singnaling protein]]
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[[Category: Structural genomic]]
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[[Category: T4l fusion]]
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[[Category: Transmembrane]]
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Revision as of 21:53, 6 November 2012


PDB ID 1a0a

Drag the structure with the mouse to rotate
1a0a, resolution 2.80Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX

Publication Abstract from PubMed

The crystal structure of a DNA-binding domain of PHO4 complexed with DNA at 2.8 A resolution revealed that the domain folds into a basic-helix-loop-helix (bHLH) motif with a long but compact loop that contains a short alpha-helical segment. This helical structure positions a tryptophan residue into an aromatic cluster so as to make the loop compact. PHO4 binds to DNA as a homodimer with direct reading of both the core E-box sequence CACGTG and its 3'-flanking bases. The 3'-flanking bases GG are recognized by Arg2 and His5. The residues involved in the E-box recognition are His5, Glu9 and Arg13, as already reported for bHLH/Zip proteins MAX and USF, and are different from those recognized by bHLH proteins MyoD and E47, although PHO4 is a bHLH protein.

Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition., Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T, EMBO J. 1997 Aug 1;16(15):4689-97. PMID:9303313

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1a0a is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J. 1997 Aug 1;16(15):4689-97. PMID:9303313 doi:10.1093/emboj/16.15.4689

Proteopedia Page Contributors and Editors (what is this?)

Myron Williams, Michal Harel

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