Grb10 SH2 Domain
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Grb10 is a member of a family of adapter proteins that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | + | Grb10 is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> |
| + | ==Dimerization of the Grb10 SH2 Domain== | ||
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| + | The crystal structure of Grb10 SH2 domain was an important step to understand how this protein interacts with IGF1 receptors and although the SH2 domain functions as an independent segment, it forms a dimer in physiological environments. <scene name='Grb10_SH2_Domain/Dimer_interface/1'>Dimer Interface</scene> | ||
</StructureSection> | </StructureSection> | ||
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Revision as of 23:39, 6 November 2012
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References
- ↑ Stein EG, Ghirlando R, Hubbard SR. Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity. J Biol Chem. 2003 Apr 11;278(15):13257-64. Epub 2003 Jan 27. PMID:12551896 doi:http://dx.doi.org/10.1074/jbc.M212026200
