1pp5
From Proteopedia
(New page: 200px<br /><applet load="1pp5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pp5" /> '''Structure of Antibacterial Peptide Microcin ...) |
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| - | [[Image:1pp5.gif|left|200px]]<br /><applet load="1pp5" size=" | + | [[Image:1pp5.gif|left|200px]]<br /><applet load="1pp5" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''<br /> | '''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1PP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bayro, M | + | [[Category: Bayro, M J.]] |
| - | [[Category: Ebright, R | + | [[Category: Ebright, R H.]] |
| - | [[Category: Huang, J | + | [[Category: Huang, J Y.]] |
| - | [[Category: Ma, L | + | [[Category: Ma, L C.]] |
| - | [[Category: Montelione, G | + | [[Category: Montelione, G T.]] |
[[Category: Mukhopadhyay, J.]] | [[Category: Mukhopadhyay, J.]] | ||
| - | [[Category: NESG, Northeast | + | [[Category: NESG, Northeast Structural Genomics Consortium.]] |
| - | [[Category: Swapna, G | + | [[Category: Swapna, G V.T.]] |
[[Category: backbone-sidechain amide linkage]] | [[Category: backbone-sidechain amide linkage]] | ||
[[Category: lariat]] | [[Category: lariat]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:31:02 2008'' |
Revision as of 12:31, 21 February 2008
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Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot
Overview
The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle. Here, we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact is a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through the cyclic segment. MccJ25 is the first example of a lariat protoknot involving a backbone-side chain amide linkage.
About this Structure
1PP5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot., Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH, J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:14531661
Page seeded by OCA on Thu Feb 21 14:31:02 2008
Categories: Escherichia coli | Single protein | Bayro, M J. | Ebright, R H. | Huang, J Y. | Ma, L C. | Montelione, G T. | Mukhopadhyay, J. | NESG, Northeast Structural Genomics Consortium. | Swapna, G V.T. | Backbone-sidechain amide linkage | Lariat | Nesg | Northeast structural genomics consortium | Protein structure initiative | Protoknot | Psi | Structural genomics
