Lambda repressor
From Proteopedia
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[[Image:1lmb.png|left|200px]] | [[Image:1lmb.png|left|200px]] | ||
| - | <StructureSection load='1lmb' size='350' side='right' caption='Structure of Lambda Repressor cI (PDB entry [[1lmb]])' scene=''></StructureSection> | ||
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== Bacteriophage Lambda Repressor cI == | == Bacteriophage Lambda Repressor cI == | ||
| - | cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved by cI through repression of the ''cro'' gene and the ''cI'' gene, which code for proteins Cro and cI, respectively. Transition from the lysogenic to lytic life cycle will not occur unless the cellular concentration of Cro becomes larger than the cellular concentration of cI. | + | cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved by cI through repression of the ''cro'' gene and the ''cI'' gene, which code for proteins Cro and cI, respectively. Transition from the lysogenic to lytic life cycle will not occur unless the cellular concentration of Cro becomes larger than the cellular concentration of cI. |
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| + | <StructureSection load='1lmb' size='350' side='right' caption='Structure of Lambda Repressor cI (PDB entry [[1lmb]])' scene=''></StructureSection> | ||
==About this Structure== | ==About this Structure== | ||
Revision as of 04:35, 8 November 2012
Bacteriophage Lambda Repressor cI
cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved by cI through repression of the cro gene and the cI gene, which code for proteins Cro and cI, respectively. Transition from the lysogenic to lytic life cycle will not occur unless the cellular concentration of Cro becomes larger than the cellular concentration of cI.
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About this Structure
1LMB is a 4 chains structure of sequences from Enterobacteria phage lambda. This structure supersedes the now removed PDB entry 1lrd. Full crystallographic information is available from OCA.
Reference
- Beamer LJ, Pabo CO. Refined 1.8 A crystal structure of the lambda repressor-operator complex. J Mol Biol. 1992 Sep 5;227(1):177-96. PMID:1387915
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Wally Novak, Michal Harel, Alexander Berchansky, Jaime Prilusky
