Lambda repressor
From Proteopedia
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[[Image:1lmb.png|left|200px]] | [[Image:1lmb.png|left|200px]] | ||
| - | == | + | {{STRUCTURE_3bdn| PDB=3bdn | SCENE= }} |
| - | cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved | + | == Introduction == |
| + | cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved when two repressor dimers bind cooperatively to adjacent operator sites on the DNA. The cooperative binding induces repression of the ''cro'' gene and simultaneous activation of the ''cI'' gene, which code for proteins Cro and cI, respectively. | ||
| - | <StructureSection load=' | + | ==Structural Overview== |
| + | The Lambda Repressor dimer is composed of two identical polypeptide chains of 236 amino acid residues each. | ||
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| + | <StructureSection load='3bdn' size='350' side='right' caption='Structure of Lambda Repressor cI (PDB entry [[3bdn]])' scene=''></StructureSection> | ||
| - | ==About this Structure== | ||
| - | 1LMB is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1lrd 1lrd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMB OCA]. | ||
==Reference== | ==Reference== | ||
Revision as of 07:19, 8 November 2012
Introduction
cI is a transcription inhibitor of bacteriophage Lambda. Also known as Lambda Repressor, cI is responsible for maintaining the lysogenic life cycle of phage Lambda. This is achieved when two repressor dimers bind cooperatively to adjacent operator sites on the DNA. The cooperative binding induces repression of the cro gene and simultaneous activation of the cI gene, which code for proteins Cro and cI, respectively.
Structural Overview
The Lambda Repressor dimer is composed of two identical polypeptide chains of 236 amino acid residues each.
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Reference
- Beamer LJ, Pabo CO. Refined 1.8 A crystal structure of the lambda repressor-operator complex. J Mol Biol. 1992 Sep 5;227(1):177-96. PMID:1387915
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