Nuclear receptor coactivator
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION= | + | {{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }} |
<!-- | <!-- | ||
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
Revision as of 11:10, 8 November 2012
Template:STRUCTURE 1oj5 Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA are involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA3 shows histone acetyltransferase activity.
3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
