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1pto
From Proteopedia
(New page: 200px<br /><applet load="1pto" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pto, resolution 3.5Å" /> '''THE STRUCTURE OF A PE...) |
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| - | [[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size=" | + | [[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1pto, resolution 3.5Å" /> | caption="1pto, resolution 3.5Å" /> | ||
'''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''<br /> | '''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis | + | Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines. |
==About this Structure== | ==About this Structure== | ||
| - | 1PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http:// | + | 1PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bordetella pertussis]] | [[Category: Bordetella pertussis]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Read, R | + | [[Category: Read, R J.]] |
| - | [[Category: Stein, P | + | [[Category: Stein, P E.]] |
[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:32:25 2008'' |
Revision as of 12:32, 21 February 2008
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THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING
Overview
Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.
About this Structure
1PTO is a Protein complex structure of sequences from Bordetella pertussis. Full crystallographic information is available from OCA.
Reference
Structure of a pertussis toxin-sugar complex as a model for receptor binding., Stein PE, Boodhoo A, Armstrong GD, Heerze LD, Cockle SA, Klein MH, Read RJ, Nat Struct Biol. 1994 Sep;1(9):591-6. PMID:7634099
Page seeded by OCA on Thu Feb 21 14:32:25 2008
