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Phosphoglycerate dehydrogenase
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Revision as of 08:08, 12 November 2012
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Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.
3D structures of phosphoglycerate dehydrogenase
1ygy, 3dc2 – MtPGDH – Mycobacterium tuberculosis
3evt - PGDH – Lactobacillus plantarum
3gg9 - PGDH – Ralstonia solanacearum
3k5p - PGDH (mutant) – Brucella melitensis
PGDH binary complex
1sc6, 2p9c, 2p9e, 2p9g - EcPGDH (mutant) + NAD – Escherichia coli
1yba - EcPGDH + NAD
1wwk - PGDH + NAD – Pyrococcus horikoshii
2g76 - PGDH + NAD – human
2ekl - PGDH + NAD – Sulfolobus tokodaii
3ddn - MtPGDH + hydroxypyruvic acid phosphate
PGDH ternary complex
1psd - EcPGDH + serine + NAD
2pa3 - EcPGDH (mutant) + serine + NAD
