Sean Swale/Human Thrombin Inhibitor

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== Human Thrombin Inhibitor ==
== Human Thrombin Inhibitor ==
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Thrombin is a serine protease that cleaves fibrinogen to allow fibrin to form stringy networks that trap red blood cells to form clots. Thrombin is a serine protease because it cleaves fibrinogen with its serine residue. Thrombin when made by the body is tethered to blood vessels so that it cannot cause clots throughout the body causing strokes and heart attacks. Additionally, thrombin is only activated for a few seconds to limit the clotted area to the injured area<ref>http://www.rcsb.org/pdb/education_discussion/molecule_of_the_month/download/Thrombin.pdf </ref>. In cases such as dialysis a blood thinner like hirudin is needed to make sure a blood clot is not created in the body. Unfortunately, hirudin
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Thrombin is a serine protease that cleaves fibrinogen to allow fibrin to form stringy networks that trap red blood cells to form clots. Thrombin is a serine protease because it cleaves fibrinogen with its serine residue. Thrombin when made by the body is tethered to blood vessels so that it cannot cause clots throughout the body causing strokes and heart attacks. Additionally, thrombin is only activated for a few seconds to limit the clotted area to the injured area<ref>January 2002 Molecule of the Month by David Goodsell doi: 10.2210/rcsb_pdb/mom_2002_1 </ref>. In cases such as dialysis a blood thinner like hirudin is needed to make sure a blood clot is not created in the body. Unfortunately, hirudin

Revision as of 23:26, 13 November 2012

Human Thrombin Inhibitor

Thrombin is a serine protease that cleaves fibrinogen to allow fibrin to form stringy networks that trap red blood cells to form clots. Thrombin is a serine protease because it cleaves fibrinogen with its serine residue. Thrombin when made by the body is tethered to blood vessels so that it cannot cause clots throughout the body causing strokes and heart attacks. Additionally, thrombin is only activated for a few seconds to limit the clotted area to the injured area[1]. In cases such as dialysis a blood thinner like hirudin is needed to make sure a blood clot is not created in the body. Unfortunately, hirudin


Introduction

PDB ID 3utu

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Proteopedia Page Contributors and Editors (what is this?)

Sean Swale, Michal Harel

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