Methionine adenosyltransferase
From Proteopedia
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| - | {{STRUCTURE_1mxb| PDB=1mxb | SIZE=400| SCENE= |right| CAPTION=E. coli S-adenosylmethionine synthetase complex with phosphate, ADP, Mg+2 and K+ ions, [[1mxb]] }} | + | {{STRUCTURE_1mxb| PDB=1mxb | SIZE=400| SCENE= |right| CAPTION=Monomer of the dimeric E. coli S-adenosylmethionine synthetase complex with phosphate, ADP, Mg+2 (green) and K+ (purple) ions, [[1mxb]] }} |
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Revision as of 12:17, 14 November 2012
Template:STRUCTURE 1mxb S-adenosylmethionine synthetase (MAT) catalyzes the conversion of methionine and ATP to S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi). AdoMet is a methyl donor. The catalytic entity of MAT is a dimer. MAT cofactors are Mg+2 (or Co+2) and K+ ions.
3D structures of S-adenosylmethionine synthetase
1fug – EcMAT – Escherichia coli
3iml – MAT – Burkholderia pseudomallei
2ydy – hMAT II subunit β – human
MAT complexes
1xra, 1xrb – EcMAT + Pi + K + Mg
1xrc - EcMAT + Pi + Co + K
1mxa - EcMAT + Pi + PPi + Mg + K
1mxb - EcMAT + Pi + ADP + Mg + K
1mxc - EcMAT + Pi + Br-ADP + Mg + K
1p7l – EcMAT + methionine + AdoMet + AMPPNP + Mg + K
1rg9 - EcMAT + AdoMet + AMPPNP + Mg + K
1qm4 - rMAT+ methionine analog + K + Mg – rat
1o90 - rMAT + Pi + Mg + K
1o92 – rMAT + methionine analog + ADP + Mg + K
1o93 – rMAT + methionine analog + ATP + Mg + K
1o9t – rMAT + methionine + ADP + Mg + K
2obv – hMAT I + AdoMet + Na
2p02 - hMAT II + AdoMet
2ydx – MAT + resveratrol + NADP + Ca + ADP derivative
Proteopedia Page Contributors and Editors (what is this?)
Karsten Theis, Anna Postnikova, Michal Harel, Kia Yang, Michael O'Shaughnessy, Alexander Berchansky, Jaime Prilusky
