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(New page: ==Ornithine transcarbamoylase== ====Introduction==== Ornithine transcarbamoylase (OTC) is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline...)
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Revision as of 01:20, 15 November 2012
Ornithine transcarbamoylase
Introduction
Ornithine transcarbamoylase (OTC) is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate. In plants and microbes, OTC is involved in arginine biosynthesis, but in mammals it is located in the mitochondria and is part of the urea cycle.
OTC is often associated with Ornithine transcarbamoylase deficiency (OTCD). OTCD is a common urea cycle disorder, and it is a genetic disorder which results in a mutated and ineffective form of the enzyme OTC.
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