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1gwh
From Proteopedia
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(New page: 200px<br /> <applet load="1gwh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gwh, resolution 1.74Å" /> '''ATOMIC RESOLUTION S...)
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Revision as of 14:12, 29 October 2007
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ATOMIC RESOLUTION STRUCTURE OF MICROCOCCUS LYSODEIKTICUS CATALASE COMPLEXED WITH NADPH
Overview
The crystal structure of the bacterial catalase from Micrococcus, lysodeikticus has been refined using the gene-derived sequence both at, 0.88 A resolution using data recorded at 110 K and at 1.5 A resolution, with room-temperature data. The atomic resolution structure has been, refined with individual anisotropic atomic thermal parameters. This has, revealed the geometry of the haem and surrounding protein, including many, of the H atoms, with unprecedented accuracy and has characterized, functionally important hydrogen-bond interactions in the active site. The, positions of the H atoms are consistent with the enzymatic mechanism, previously suggested for beef liver catalase. The structure reveals that a, 25 A long channel leading to the haem is filled by partially occupied, water ... [(full description)]
About this Structure
1GWH is a [Single protein] structure of sequence from [[1]] with SO4, ACT, HEM and NDP as [ligands]. Active as [[2]], with EC number [1.11.1.6]. Full crystallographic information is available from [OCA].
Reference
The structures of Micrococcus lysodeikticus catalase, its ferryl intermediate (compound II) and NADPH complex., Murshudov GN, Grebenko AI, Brannigan JA, Antson AA, Barynin VV, Dodson GG, Dauter Z, Wilson KS, Melik-Adamyan WR, Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):1972-82. Epub 2002, Nov 23. PMID:12454454
Page seeded by OCA on Mon Oct 29 16:16:43 2007
