1qc1
From Proteopedia
(New page: 200px<br /><applet load="1qc1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qc1, resolution 2.5Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1qc1.gif|left|200px]]<br /><applet load="1qc1" size=" | + | [[Image:1qc1.gif|left|200px]]<br /><applet load="1qc1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qc1, resolution 2.5Å" /> | caption="1qc1, resolution 2.5Å" /> | ||
'''CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)'''<br /> | '''CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Groove-backbone interaction is a natural and biologically relevant | + | Groove-backbone interaction is a natural and biologically relevant mechanism for the specific assembly of B-DNA double helices. Crystal engineering and crystal packing analysis of oligonucleotides of different sizes and sequences reveal that the sequence-dependent self-fitting of B-DNA helices is a dominant constraint for their ordered assembly. It can override the other intermolecular interactions and impose the overall geometry of the packing. Analysis of experimental examples of architectural motifs formed by the geometric combination of self-fitted DNA segments leads to general rules for DNA assembly. Like a directing piece for a supramolecular 'construction set', the double helix imposes a limited number of geometric solutions. These basic architectural constraints could direct, in a codified manner, the formation of higher-order structures. DNA architectural motifs exhibit new structural and electrostatic properties which could have some implications for their molecular recognition by proteins acting on DNA. |
==About this Structure== | ==About this Structure== | ||
| - | 1QC1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1QC1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: dna-dna recognition]] | [[Category: dna-dna recognition]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:07 2008'' |
Revision as of 12:38, 21 February 2008
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CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)
Overview
Groove-backbone interaction is a natural and biologically relevant mechanism for the specific assembly of B-DNA double helices. Crystal engineering and crystal packing analysis of oligonucleotides of different sizes and sequences reveal that the sequence-dependent self-fitting of B-DNA helices is a dominant constraint for their ordered assembly. It can override the other intermolecular interactions and impose the overall geometry of the packing. Analysis of experimental examples of architectural motifs formed by the geometric combination of self-fitted DNA segments leads to general rules for DNA assembly. Like a directing piece for a supramolecular 'construction set', the double helix imposes a limited number of geometric solutions. These basic architectural constraints could direct, in a codified manner, the formation of higher-order structures. DNA architectural motifs exhibit new structural and electrostatic properties which could have some implications for their molecular recognition by proteins acting on DNA.
About this Structure
1QC1 is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
DNA self-fitting: the double helix directs the geometry of its supramolecular assembly., Timsit Y, Moras D, EMBO J. 1994 Jun 15;13(12):2737-46. PMID:8026458
Page seeded by OCA on Thu Feb 21 14:38:07 2008
