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1qd9
From Proteopedia
(New page: 200px<br /><applet load="1qd9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qd9, resolution 1.70Å" /> '''Bacillus subtilis YA...) |
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| - | [[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size=" | + | [[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qd9, resolution 1.70Å" /> | caption="1qd9, resolution 1.70Å" /> | ||
'''Bacillus subtilis YABJ'''<br /> | '''Bacillus subtilis YABJ'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The yabJ gene in Bacillus subtilis is required for adenine-mediated | + | The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with HG, EMC and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=HG:'>HG</scene>, <scene name='pdbligand=EMC:'>EMC</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QD9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Lange, S | + | [[Category: Lange, S C.]] |
[[Category: Mantsala, P.]] | [[Category: Mantsala, P.]] | ||
[[Category: Rappu, P.]] | [[Category: Rappu, P.]] | ||
[[Category: Sinha, S.]] | [[Category: Sinha, S.]] | ||
| - | [[Category: Smith, J | + | [[Category: Smith, J L.]] |
[[Category: Zalkin, H.]] | [[Category: Zalkin, H.]] | ||
[[Category: ACY]] | [[Category: ACY]] | ||
| Line 27: | Line 27: | ||
[[Category: yjgf/yer057c family]] | [[Category: yjgf/yer057c family]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:24 2008'' |
Revision as of 12:38, 21 February 2008
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Bacillus subtilis YABJ
Overview
The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins.
About this Structure
1QD9 is a Single protein structure of sequence from Bacillus subtilis with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family., Sinha S, Rappu P, Lange SC, Mantsala P, Zalkin H, Smith JL, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13074-9. PMID:10557275
Page seeded by OCA on Thu Feb 21 14:38:24 2008
