1qdn
From Proteopedia
(New page: 200px<br /><applet load="1qdn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qdn, resolution 2.30Å" /> '''AMINO TERMINAL DOMAI...) |
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| - | [[Image:1qdn.jpg|left|200px]]<br /><applet load="1qdn" size=" | + | [[Image:1qdn.jpg|left|200px]]<br /><applet load="1qdn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qdn, resolution 2.30Å" /> | caption="1qdn, resolution 2.30Å" /> | ||
'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''<br /> | '''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) | + | The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure. |
==About this Structure== | ==About this Structure== | ||
| - | 1QDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with SO4 and BME as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1QDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: May, A | + | [[Category: May, A P.]] |
| - | [[Category: Misura, K | + | [[Category: Misura, K M.S.]] |
| - | [[Category: Weis, W | + | [[Category: Weis, W I.]] |
| - | [[Category: Whiteheart, S | + | [[Category: Whiteheart, S W.]] |
[[Category: BME]] | [[Category: BME]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: vesicular-fusion protein]] | [[Category: vesicular-fusion protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:39 2008'' |
Revision as of 12:38, 21 February 2008
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AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)
Overview
The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.
About this Structure
1QDN is a Single protein structure of sequence from Cricetulus griseus with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905
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