This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1qdn
From Proteopedia
(New page: 200px<br /><applet load="1qdn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qdn, resolution 2.30Å" /> '''AMINO TERMINAL DOMAI...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1qdn.jpg|left|200px]]<br /><applet load="1qdn" size=" | + | [[Image:1qdn.jpg|left|200px]]<br /><applet load="1qdn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qdn, resolution 2.30Å" /> | caption="1qdn, resolution 2.30Å" /> | ||
'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''<br /> | '''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) | + | The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure. |
==About this Structure== | ==About this Structure== | ||
| - | 1QDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with SO4 and BME as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1QDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDN OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: May, A | + | [[Category: May, A P.]] |
| - | [[Category: Misura, K | + | [[Category: Misura, K M.S.]] |
| - | [[Category: Weis, W | + | [[Category: Weis, W I.]] |
| - | [[Category: Whiteheart, S | + | [[Category: Whiteheart, S W.]] |
[[Category: BME]] | [[Category: BME]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
| Line 22: | Line 22: | ||
[[Category: vesicular-fusion protein]] | [[Category: vesicular-fusion protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:39 2008'' |
Revision as of 12:38, 21 February 2008
|
AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)
Overview
The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.
About this Structure
1QDN is a Single protein structure of sequence from Cricetulus griseus with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905
Page seeded by OCA on Thu Feb 21 14:38:39 2008
