1qg9

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(New page: 200px<br /><applet load="1qg9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qg9" /> '''SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SO...)
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[[Image:1qg9.gif|left|200px]]<br /><applet load="1qg9" size="350" color="white" frame="true" align="right" spinBox="true"
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'''SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL'''<br />
'''SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL'''<br />
==Overview==
==Overview==
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Peptides representing transmembrane regions of the alpha-subunit of the, voltage-gated sodium channel were synthesised and their structures, analysed, using 1H NMR and CD, in trifluoroethanol and in, dodecylphosphocholine micelles. Sequence analysis suggests that the, channel has six regions, S1 to S6, predicted to span the membrane in four, homologous domains, designated, I, II, III and IV. Presented here are, studies of representatives examples of possible single spanning segments, (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments, IS3 and IS4. In addition, we investigated ISlink56, the putative linker, region between segments IS5 and IS6. All of the peptides were found to, have predominantly alpha-helical structures in both solvent systems. There, was some evidence for bending of the longer helices but there was no, discernible evidence for well-defined tertiary structure.
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Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure.
==About this Structure==
==About this Structure==
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1QG9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QG9 OCA].
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1QG9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG9 OCA].
==Reference==
==Reference==
Structural studies of synthetic peptides dissected from the voltage-gated sodium channel., Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID, J Mol Biol. 1996 May 17;258(4):672-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8637001 8637001]
Structural studies of synthetic peptides dissected from the voltage-gated sodium channel., Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID, J Mol Biol. 1996 May 17;258(4):672-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8637001 8637001]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Campbell, I.D.]]
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[[Category: Campbell, I D.]]
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[[Category: Doak, D.J.]]
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[[Category: Doak, D J.]]
[[Category: Kawaguchi, K.]]
[[Category: Kawaguchi, K.]]
[[Category: Mulvey, D.]]
[[Category: Mulvey, D.]]
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[[Category: transmembrane sodium channel]]
[[Category: transmembrane sodium channel]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:39:53 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:11 2008''

Revision as of 12:39, 21 February 2008

Image:1qg9.gif

1qg9

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SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL

Overview

Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure.

About this Structure

1QG9 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structural studies of synthetic peptides dissected from the voltage-gated sodium channel., Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID, J Mol Biol. 1996 May 17;258(4):672-87. PMID:8637001

Page seeded by OCA on Thu Feb 21 14:39:11 2008

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