4d83

(Difference between revisions)

Revision as of 09:26, 21 November 2012

4d83 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Rueeger H, Rondeau JM, McCarthy C, Mobitz H, Tintelnot-Blomley M, Neumann U, Desrayaud S. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1942-7. Epub 2011 Feb 15. PMID:21388807 doi:10.1016/j.bmcl.2011.02.038

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-'''Unreleased structure'''
+[[Image:4d83.jpg|left|200px]]
-The entry 4d83 is ON HOLD  until Paper Publication
+{{STRUCTURE_4d83|  PDB=4d83  |  SCENE=  }}
-Authors: Rondeau, J.M., Bourgier, E.
+===Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment===
-Description: Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment
+{{ABSTRACT_PUBMED_22380629}}
+==About this Structure==
+[[4d83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D83 OCA].
+==Reference==
+<ref group="xtra">PMID:021388807</ref><references group="xtra"/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Bourgier, E.]]
+[[Category: Rondeau, J M.]]
+[[Category: Alzheimer's disease]]
+[[Category: Aspartic proteinase]]
+[[Category: Bace1]]
+[[Category: Beta-secretase]]
+[[Category: Enzyme inhibitor complex]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Memapsin2]]
+[[Category: Structure-based drug design]]