1qgt
From Proteopedia
(New page: 200px<br /><applet load="1qgt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qgt, resolution 3.3Å" /> '''HUMAN HEPATITIS B VIR...) |
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| - | [[Image:1qgt.gif|left|200px]]<br /><applet load="1qgt" size=" | + | [[Image:1qgt.gif|left|200px]]<br /><applet load="1qgt" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qgt, resolution 3.3Å" /> | caption="1qgt, resolution 3.3Å" /> | ||
'''HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)'''<br /> | '''HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Hepatitis B is a small enveloped DNA virus that poses a major hazard to | + | Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface. |
==About this Structure== | ==About this Structure== | ||
| - | 1QGT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus]. Full crystallographic information is available from [http:// | + | 1QGT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Hepatitis b virus]] | [[Category: Hepatitis b virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Crowther, R | + | [[Category: Crowther, R A.]] |
| - | [[Category: Leslie, A | + | [[Category: Leslie, A G.W.]] |
| - | [[Category: Wynne, S | + | [[Category: Wynne, S A.]] |
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
[[Category: viral capsid protein]] | [[Category: viral capsid protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:26 2008'' |
Revision as of 12:39, 21 February 2008
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HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)
Overview
Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
About this Structure
1QGT is a Single protein structure of sequence from Hepatitis b virus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the human hepatitis B virus capsid., Wynne SA, Crowther RA, Leslie AG, Mol Cell. 1999 Jun;3(6):771-80. PMID:10394365
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