1qhi
From Proteopedia
(New page: 200px<br /><applet load="1qhi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qhi, resolution 1.9Å" /> '''HERPES SIMPLEX VIRUS ...) |
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| - | [[Image:1qhi.gif|left|200px]]<br /><applet load="1qhi" size=" | + | [[Image:1qhi.gif|left|200px]]<br /><applet load="1qhi" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qhi, resolution 1.9Å" /> | caption="1qhi, resolution 1.9Å" /> | ||
'''HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'''<br /> | '''HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Treatment of herpes infections with nucleoside analogues requires as an | + | Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties. |
==About this Structure== | ==About this Structure== | ||
| - | 1QHI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with SO4 and BPG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Full crystallographic information is available from [http:// | + | 1QHI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=BPG:'>BPG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
[[Category: Batuwangala, T.]] | [[Category: Batuwangala, T.]] | ||
| - | [[Category: Bennett, M | + | [[Category: Bennett, M S.]] |
| - | [[Category: Champness, J | + | [[Category: Champness, J N.]] |
[[Category: Rutherford, T.]] | [[Category: Rutherford, T.]] | ||
| - | [[Category: Sanderson, M | + | [[Category: Sanderson, M R.]] |
| - | [[Category: Summers, W | + | [[Category: Summers, W C.]] |
[[Category: Sun, H.]] | [[Category: Sun, H.]] | ||
[[Category: Wien, F.]] | [[Category: Wien, F.]] | ||
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[[Category: transferase (phosphotransferase) thymidine]] | [[Category: transferase (phosphotransferase) thymidine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:36 2008'' |
Revision as of 12:39, 21 February 2008
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HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Overview
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
About this Structure
1QHI is a Single protein structure of sequence from Human herpesvirus 4 with and as ligands. Active as Thymidine kinase, with EC number 2.7.1.21 Full crystallographic information is available from OCA.
Reference
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588
Page seeded by OCA on Thu Feb 21 14:39:36 2008
Categories: Human herpesvirus 4 | Single protein | Thymidine kinase | Batuwangala, T. | Bennett, M S. | Champness, J N. | Rutherford, T. | Sanderson, M R. | Summers, W C. | Sun, H. | Wien, F. | Wright, G. | BPG | SO4 | Transferase | Transferase ( phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae novel inhibitor | Transferase (phosphotransferase) thymidine
