1qoj
From Proteopedia
(New page: 200px<br /><applet load="1qoj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qoj, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1qoj.gif|left|200px]]<br /><applet load="1qoj" size=" | + | [[Image:1qoj.gif|left|200px]]<br /><applet load="1qoj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qoj, resolution 3.0Å" /> | caption="1qoj, resolution 3.0Å" /> | ||
'''CRYSTAL STRUCTURE OF E.COLI UVRB C-TERMINAL DOMAIN, AND A MODEL FOR UVRB-UVRC INTERACTION.'''<br /> | '''CRYSTAL STRUCTURE OF E.COLI UVRB C-TERMINAL DOMAIN, AND A MODEL FOR UVRB-UVRC INTERACTION.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A crystal structure of the C-terminal domain of Escherichia coli UvrB | + | A crystal structure of the C-terminal domain of Escherichia coli UvrB (UvrB') has been solved to 3.0 A resolution. The domain adopts a helix-loop-helix fold which is stabilised by the packing of hydrophobic side-chains between helices. From the UvrB' fold, a model for a domain of UvrC (UvrC') that has high sequence homology with UvrB' has been made. In the crystal, a dimerisation of UvrB domains is seen involving specific hydrophobic and salt bridge interactions between residues in and close to the loop region of the domain. It is proposed that a homologous mode of interaction may occur between UvrB and UvrC. This interaction is likely to be flexible, potentially spanning > 50 A. |
==About this Structure== | ==About this Structure== | ||
| - | 1QOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1QOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Goosen, N.]] | [[Category: Goosen, N.]] | ||
[[Category: Moolenaar, G.]] | [[Category: Moolenaar, G.]] | ||
| - | [[Category: Sanderson, M | + | [[Category: Sanderson, M R.]] |
[[Category: Sohi, M.]] | [[Category: Sohi, M.]] | ||
[[Category: Vernede, X.]] | [[Category: Vernede, X.]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:42:02 2008'' |
Revision as of 12:42, 21 February 2008
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CRYSTAL STRUCTURE OF E.COLI UVRB C-TERMINAL DOMAIN, AND A MODEL FOR UVRB-UVRC INTERACTION.
Overview
A crystal structure of the C-terminal domain of Escherichia coli UvrB (UvrB') has been solved to 3.0 A resolution. The domain adopts a helix-loop-helix fold which is stabilised by the packing of hydrophobic side-chains between helices. From the UvrB' fold, a model for a domain of UvrC (UvrC') that has high sequence homology with UvrB' has been made. In the crystal, a dimerisation of UvrB domains is seen involving specific hydrophobic and salt bridge interactions between residues in and close to the loop region of the domain. It is proposed that a homologous mode of interaction may occur between UvrB and UvrC. This interaction is likely to be flexible, potentially spanning > 50 A.
About this Structure
1QOJ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-uvrC interaction., Sohi M, Alexandrovich A, Moolenaar G, Visse R, Goosen N, Vernede X, Fontecilla-Camps JC, Champness J, Sanderson MR, FEBS Lett. 2000 Jan 14;465(2-3):161-4. PMID:10631326
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