1qqd
From Proteopedia
(New page: 200px<br /> <applet load="1qqd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qqd, resolution 2.70Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1qqd.gif|left|200px]]<br /> | + | [[Image:1qqd.gif|left|200px]]<br /><applet load="1qqd" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1qqd" size=" | + | |
caption="1qqd, resolution 2.70Å" /> | caption="1qqd, resolution 2.70Å" /> | ||
'''CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR'''<br /> | '''CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the human class I major histocompatibility | + | The crystal structure of the human class I major histocompatibility complex molecule, human histocompatibility leukocyte antigen (HLA)-Cw4, the ligand for a natural killer (NK) cell inhibitory receptor, has been determined, complexed with a nonameric consensus peptide (QYDDAVYKL). Relative to HLA-A2, the peptide binding groove is widened around the COOH terminus of the alpha 1 helix, which contains residues that determine the specificity of HLA-Cw4 for the inhibitory NK receptor, KIR2D. The structure reveals an unusual pattern of internal hydrogen bonding among peptide residues. The peptide is anchored in four specificity pockets in the cleft and secured by extensive hydrogen bonds between the peptide main chain and the cleft. The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QQD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1QQD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Fan, Q | + | [[Category: Fan, Q R.]] |
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: alpha helix]] | [[Category: alpha helix]] | ||
[[Category: beta sheet]] | [[Category: beta sheet]] | ||
[[Category: immunoglobulin (ig)-like domain]] | [[Category: immunoglobulin (ig)-like domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:42:36 2008'' |
Revision as of 12:42, 21 February 2008
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CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR
Contents |
Overview
The crystal structure of the human class I major histocompatibility complex molecule, human histocompatibility leukocyte antigen (HLA)-Cw4, the ligand for a natural killer (NK) cell inhibitory receptor, has been determined, complexed with a nonameric consensus peptide (QYDDAVYKL). Relative to HLA-A2, the peptide binding groove is widened around the COOH terminus of the alpha 1 helix, which contains residues that determine the specificity of HLA-Cw4 for the inhibitory NK receptor, KIR2D. The structure reveals an unusual pattern of internal hydrogen bonding among peptide residues. The peptide is anchored in four specificity pockets in the cleft and secured by extensive hydrogen bonds between the peptide main chain and the cleft. The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D.
Disease
Known diseases associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700], Psoriasis, early onset, susceptibility to OMIM:[142840]
About this Structure
1QQD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor., Fan QR, Wiley DC, J Exp Med. 1999 Jul 5;190(1):113-23. PMID:10429675
Page seeded by OCA on Thu Feb 21 14:42:36 2008
