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1h0r

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Revision as of 16:11, 21 November 2012

Image:1h0r.png

Template:STRUCTURE 1h0r

TYPE II DEHYDROQUINASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH 2,3-ANHYDRO-QUINIC ACID

Template:ABSTRACT PUBMED 10360352

About this Structure

1h0r is a 1 chain structure with sequence from Mycobacterium tuberculosis. The April 2010 RCSB PDB Molecule of the Month feature on Concanavalin A and Circular Permutation by David Goodsell is 10.2210/rcsb_pdb/mom_2010_4. Full crystallographic information is available from OCA.

Reference

  • Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L. The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol. 1999 Jun;6(6):521-5. PMID:10360352 doi:http://dx.doi.org/10.1038/9287
  • Prazeres VF, Sanchez-Sixto C, Castedo L, Canales A, Canada FJ, Jimenez-Barbero J, Lamb H, Hawkins AR, Gonzalez-Bello C. Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy. ChemMedChem. 2006 Sep;1(9):990-6. PMID:16952136 doi:10.1002/cmdc.200600100

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OCA

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