1h9d
From Proteopedia
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[[Image:1h9d.png|left|200px]] | [[Image:1h9d.png|left|200px]] | ||
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{{STRUCTURE_1h9d| PDB=1h9d | SCENE= }} | {{STRUCTURE_1h9d| PDB=1h9d | SCENE= }} | ||
===AML1/CBF-BETA/DNA COMPLEX=== | ===AML1/CBF-BETA/DNA COMPLEX=== | ||
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{{ABSTRACT_PUBMED_11276260}} | {{ABSTRACT_PUBMED_11276260}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Platelet disorder, familial, with associated myeloid malignancy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Rheumatoid arthritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Myeloid leukemia, acute, M4Eo subtype OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=121360 121360]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1h9d]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9D OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:011276260</ref><ref group="xtra">PMID:012217689</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bravo, J.]] | [[Category: Bravo, J.]] | ||
[[Category: Warren, A J.]] | [[Category: Warren, A J.]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:27:11 2009'' | ||
Revision as of 16:16, 21 November 2012
AML1/CBF-BETA/DNA COMPLEX
Template:ABSTRACT PUBMED 11276260
About this Structure
1h9d is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:http://dx.doi.org/10.1038/86264
- Backstrom S, Wolf-Watz M, Grundstrom C, Hard T, Grundstrom T, Sauer UH. The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. J Mol Biol. 2002 Sep 13;322(2):259-72. PMID:12217689
