Sandbox Reserved 651
From Proteopedia
(Difference between revisions)
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== Introduction == | == Introduction == | ||
| - | The retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA. | + | The retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA.<ref>1<re/> In turn the newly developed DNA can then be incorporated into the host cell genome. The HIV-1 reverse transcriptase enzyme has two domains within its structure. The two domains are a DNA polymerase domain and ribonuclease H (also called RNase H) domain. The role of the DNA polymerase is to copy either RNA or DNA template strands. The purpose of the ribonuclease H is to cleave the RNA duplex after the DNA synthesis has occurred so that the newly created DNA can generate a second strand.<ref>2<ref/> |
== Structure == | == Structure == | ||
<Structure load='1FK9' size='500' frame='true' align='right' caption='HIV-1 RT in complex with efavirenz' scene='Insert optional scene name here' /> | <Structure load='1FK9' size='500' frame='true' align='right' caption='HIV-1 RT in complex with efavirenz' scene='Insert optional scene name here' /> | ||
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'''Non-nucleotide RT Inhibitors''' | '''Non-nucleotide RT Inhibitors''' | ||
| - | NNRTI's are non-competitive inhibitors that bind to a specific site on the enzyme but not to the active site. These molecules are typically hydrophobic and bind to a hydrophobic pocket on RT that is in close proximity to the active site. There are some NNRTIs that have been found that do not follow this general scheme and bind to alternative locations on the enzyme, these locations vary with each inhibitor. NNRTIs are highly specific and rarely have any effect on more than one strain of HIV. | + | NNRTI's are non-competitive inhibitors that bind to a specific site on the enzyme but not to the active site. These molecules are typically hydrophobic and bind to a hydrophobic pocket on RT that is in close proximity to the active site. There are some NNRTIs that have been found that do not follow this general scheme and bind to alternative locations on the enzyme, these locations vary with each inhibitor. NNRTIs are highly specific and rarely have any effect on more than one strain of HIV. |
==References== | ==References== | ||
<references/> | <references/> | ||
| + | Herschhorn, Alon, Iris Oz-Gleenberg, and Amnon Hizi. "Mechanism of Inhibition of HIV-1 Reverse Transcriptase by the Novel Broad-Range DNA Polyermerase Inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide." Biochemistry 47(2008): 490-502. | ||
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| + | Grohmann, Dina, Julien Godet, Yves Mely, Jean-Luc Darlix, and Tobias Restle. "HIV-1 Nucleocapsid Traps Reverse Transcriptase on Nucleic Acid Substrates." Biochemistry 47(2008): 12230-12240 | ||
Revision as of 21:05, 26 November 2012
| This Sandbox is Reserved from 30/08/2012, through 01/02/2013 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 636 through Sandbox Reserved 685. |
To get started:
More help: Help:Editing For more help, look at this link: http://proteopedia.org/w/Help:Getting_Started_in_Proteopedia Human Immunodeficiency Virus-1 Reverse TranscriptaseIntroductionThe retrovirus human immunodeficiency virus (HIV) is a subsequent progression to acquired immune deficiency syndrome (AIDS). This disease is a continuous worldwide epidemic. The protein HIV-1 reverse transcriptase is one of the key players in the mechanism of infections by this retrovirus. The protein HIV-I reverse transcriptase is the enzyme that’s main responsibility is to copy a single-stranded viral RNA genome into a double stranded DNA.[1] |
