User:Sruti Aiyaswamy/Sandbox 1

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==MR1-restricted MAIT Activation==
==MR1-restricted MAIT Activation==
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<Structure load='4DZB' size='300' frame='true' align='right' caption='MAIT Cell Receptor' scene='' />
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<Structure load='4DZB' size='250' frame='true' align='right' caption='MAIT Cell Receptor' scene='' />
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==Biological Significance==

Revision as of 08:25, 27 November 2012

Contents

Introduction

The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells. It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells.

MR1 is MHC Class I Related

MHC Class I in complex with peptide

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Where does this lead?


















Finally relate how MHC structure/function is similar to MR1. Explain chains, b2m, folding.

Structure of MR1-antigen Complex

Structure of MR1 in complex with b2m and 6-formyl

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MR1-restricted MAIT Activation

MAIT Cell Receptor

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Biological Significance

Proteopedia Page Contributors and Editors (what is this?)

Sruti Aiyaswamy

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