User:Sruti Aiyaswamy/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
| - | The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells. It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells. | + | The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells.<ref> PMID: 19410687 </ref> It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells. |
==MR1 is MHC Class I Related== | ==MR1 is MHC Class I Related== | ||
| Line 31: | Line 31: | ||
==Biological Significance== | ==Biological Significance== | ||
| + | |||
| + | ==References== | ||
| + | <references /> | ||
Revision as of 08:27, 27 November 2012
Contents |
Introduction
The MHC class I-like molecule, MR1, is an antigen presenting protein that specifically activates mucosal-associated invariant T (MAIT) cells.[1] It has been found that microbial vitamin B metabolites serve as MR1 ligands that activate the MAIT cells.
MR1 is MHC Class I Related
|
Finally relate how MHC structure/function is similar to MR1. Explain chains, b2m, folding.
Structure of MR1-antigen Complex
| |||||||||||
MR1-restricted MAIT Activation
|
Biological Significance
References
- ↑ Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol. 2009 May;123(5):977-83; quiz 984-5. PMID:19410687 doi:10.1016/j.jaci.2009.03.030
