Malarial Dihydrofolate Reductase as Drug Target
From Proteopedia
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== Introduction == | == Introduction == | ||
| + | There are currently antimalarial drugs that target the malarial dihydrofolate reductase (DHFR) such as pyrimethamine and cycloguanil. However, the effectiveness of these drugs has decreased because of mutations in the enzyme that have led to drug resistance. | ||
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<StructureSection load='3QGT' size='350' side='right' caption='Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE (PDB entry [[3QGT]])' scene=''> | <StructureSection load='3QGT' size='350' side='right' caption='Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE (PDB entry [[3QGT]])' scene=''> | ||
Anything in this section will appear adjacent to the 3D structure and will be scrollable. | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 05:12, 28 November 2012
Introduction
There are currently antimalarial drugs that target the malarial dihydrofolate reductase (DHFR) such as pyrimethamine and cycloguanil. However, the effectiveness of these drugs has decreased because of mutations in the enzyme that have led to drug resistance.
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Proteopedia Page Contributors and Editors (what is this?)
Mary Smith, Alexander Berchansky, Karsten Theis, Michal Harel
