1r02
From Proteopedia
(New page: 200px<br /> <applet load="1r02" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r02" /> '''Solution structure of Human Orexin-A:Regula...) |
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'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness'''<br /> | '''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are | + | Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1R02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hong, E.]] | [[Category: Hong, E.]] | ||
| - | [[Category: Kim, H | + | [[Category: Kim, H Y.]] |
| - | [[Category: Kim, J | + | [[Category: Kim, J I.]] |
[[Category: Lee, W.]] | [[Category: Lee, W.]] | ||
[[Category: helix-loop-helix]] | [[Category: helix-loop-helix]] | ||
[[Category: turn]] | [[Category: turn]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:31 2008'' |
Revision as of 12:45, 21 February 2008
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Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness
Contents |
Overview
Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
Disease
Known diseases associated with this structure: Narcolepsy OMIM:[602358], Porphyria variegata OMIM:[600923]
About this Structure
1R02 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620
Page seeded by OCA on Thu Feb 21 14:45:31 2008
Categories: Single protein | Hong, E. | Kim, H Y. | Kim, J I. | Lee, W. | Helix-loop-helix | Turn
